0427541 - ÚŽFG 2015 RIV IN eng J - Journal Article
Poučková, P. - Zadinová, M. - Kalous, Jaroslav - Souček, J. - Pechar, Michal - Matoušek, Josef
The antitumour effect of ribonucleases and antiangiogenins on human tumours in nude mice.
Trends in Cancer Research. Roč. 9, č. 1 (2013), s. 43-51. ISSN 0973-1040
R&D Projects: GA ČR GA521/09/1214
Institutional support: RVO:67985904 ; RVO:61389013
Keywords : angiogenin * antitumour * aspermatogenesis * bovine
Subject RIV: EB - Genetics ; Molecular Biology; CD - Macromolecular Chemistry (UMCH-V)
http://www.researchtrends.net/tia/abstract.asp?in=0&vn=9&tid=57&aid=5

Bovine seminal ribonuclease (BS-RNase) and bovine pancreatic ribonuclease (RNase A) have potent antitumour activity. In this study, the antitumour effect of selected low-toxic antiangiogenins of natural origin and bovine ribonucleases conjugated with polyethylene glycol (PEG) was tested. The antiangiogenins were selected according their toxicity. The antitumour activity of PEGylated BS-RNase and RNase A was enhanced when injected together with antiangiogenins into the athymic nude mice bearing human pancreatic tumours and human melanoma C-32 tumours.
Permanent Link: http://hdl.handle.net/11104/0233073