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Silver-coated monolithic columns for separation in radiopharmaceutical applications
- 1.0427359 - ÚMCH 2015 RIV DE eng J - Journal Article
Sedláček, Ondřej - Kučka, Jan - Švec, F. - Hrubý, Martin
Silver-coated monolithic columns for separation in radiopharmaceutical applications.
Journal of Separation Science. Roč. 37, č. 7 (2014), s. 798-802. ISSN 1615-9306. E-ISSN 1615-9314
R&D Projects: GA ČR GA202/09/2078; GA MPO FR-TI4/625
Grant - others:AV ČR(CZ) M200501201
Program: M
Institutional support: RVO:61389013
Keywords : capture * Iodide * Iodine
Subject RIV: BO - Biophysics
Impact factor: 2.737, year: 2014
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In-house-prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m-iodobenzylguanidine labeled with radionuclide iodine-125.
Permanent Link: http://hdl.handle.net/11104/0233337
Number of the records: 1