Platelet-Rich Plasma in Temporomandibular Joint Osteoarthritis Therapy: A 3-Month Follow-Up Pilot Study

0426783 - FGÚ 2015 RIV US eng J - Journal Article
Machoň, V. - Řehořová, M. - Šedý, Jiří - Foltán, R.
Platelet-Rich Plasma in Temporomandibular Joint Osteoarthritis Therapy: A 3-Month Follow-Up Pilot Study.
Journal of Arthritis. Roč. 2, č. 2 (2013), s. 100112. ISSN 2167-7921
Institutional support: RVO:67985823
Keywords : platelet-rich plasma * temporomandibular joint * osteoarthritis
Subject RIV: ED - Physiology

The use of Platelet-Rich-Plasma (PRP) may provide a new and improved treatment option for early Temporomandibular Joint (TMJ) Osteoarthritis (OA). However, there are no studies on its use in TMJ arthritis in the literature. The present study compares 30 early onsets OA patients divided equally into 3 groups who had experienced no pain reduction following conservative and minimally invasive arthrocentesis and arthroscopy treatment. All patients had retrodiscitis and synovitis on arthroscopic examination and were without systemic joint disease, septic, or autoimmune arthritis. Only patients with unilateral TMJ symptoms were included in this study. Pain intensity was recorded for each patient using a 0-10 VAS scale. Maximum Interincisal Opening (MIO) was also recorded. This assessment was performed at the pretreatment and then at an examination 3 months after administration of 2 intra-articular applications of autologous PRP (Group A), 2 intra-articular injections of Hyaluronic Acid (HA) (Group B), or commencement of conservative therapy only with soft diet and analgetics (Group C). The results after 3 months revealed that intra-articular injection of autologous PRP appeared to be an effective treatment method for patients with early OA in this study. At the 3-month follow-up, patients from group A improved their mouth opening significantly. Majority of the PRP patients (Group A) showed decreased pain. The average pain score before PRP administration was 7, while 3 months after PRP administration the pain score was 3.5. In conclusion, the use of PRP is an effective treatment option for early TMJ OA
Permanent Link: http://hdl.handle.net/11104/0239523