Monodisperse macroporous poly(glycidyl methacrylate) microspheres coated with silica: Design, preparation and characterization

0425554 - ÚMCH 2014 RIV NL eng J - Journal Article
Grama, Silvia - Plichta, Zdeněk - Trchová, Miroslava - Kovářová, Jana - Beneš, Milan J. - Horák, Daniel
Monodisperse macroporous poly(glycidyl methacrylate) microspheres coated with silica: Design, preparation and characterization.
Reactive and Functional Polymers. Roč. 77, April (2014), s. 11-17. ISSN 1381-5148. E-ISSN 1873-166X
R&D Projects: GA MŠMT EE2.3.30.0029
Institutional support: RVO:61389013
Keywords : multistep swelling polymerization * poly(glycidyl methacrylate) * poly(2,3-dihydroxypropyl methacrylate)
Subject RIV: CE - Biochemistry
Impact factor: 2.515, year: 2014

Monosized macroporous poly(glycidyl methacrylate) (PGMA) microspheres that were 9.3 μm in size were synthesized by multistep swelling polymerization using a modified Ugelstad technique. The PGMA microspheres and their hydrolyzed analogs derived from poly(2,3-dihydroxypropyl methacrylate) (PDHPMA) were coated by silanization with tetraethoxysilane (TEOS) and (3-aminopropyl)trimethoxysilane (APTES), respectively. The particles were characterized by elemental and thermogravimetric (TGA) analysis, scanning and transmission electron microscopy (SEM and TEM) coupled with an energy dispersive X-ray analysis (EDAX) and FT-IR spectroscopy to determine the SiO2 content, morphology, particle size, polydispersity and structure. These types of particles are expected to have improved biokompatibility relative to their starting polymers.
Permanent Link: http://hdl.handle.net/11104/0231423