A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs

0424945 - FGÚ 2014 RIV GB eng J - Journal Article
Filová, E. - Rampichová, M. - Litvinec, Andrej - Držík, M. - Míčková, A. - Buzgo, M. - Košťáková, E. - Martinová, L. - Usvald, D. - Prosecká, E. - Uhlík, J. - Motlík, J. - Vajner, L. - Amler, E.
A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs.
International Journal of Pharmaceutics. Roč. 447, 1-2 (2013), s. 139-149. ISSN 0378-5173. E-ISSN 1873-3476
Institutional support: RVO:67985823
Keywords : cartilage * fibrin * nanofibers
Subject RIV: FP - Other Medical Disciplines
Impact factor: 3.785, year: 2013

A novel drug delivery system was developed on the basis of the intake effect of liposomes encapsulated in PVA nanofibers. Time-controlled release of insulin and bFGF improved MSC viability in vitro. In addition, cell-free composite scaffolds containing PVA nanofibers enriched with liposomes, bFGF, and insulin were implanted into seven osteochondral defects of miniature pigs; control defects were left untreated. The cell-free composite scaffold enhanced migration of the cells into the defect, and their differentiation into chondrocytes; the scaffold was able to enhance the regeneration of osteochondral defects in minipigs
Permanent Link: http://hdl.handle.net/11104/0230930