Function of chromatin structure and dynamics in DNA damage, repair and misrepair: gamma-rays and protons in action

0424749 - BFÚ 2014 RIV GB eng J - Journal Article
Ježková, L. - Falk, Martin - Falková, Iva - Davídková, Marie - Bačíková, Alena - Štefančíková, Lenka - Vachelová, Jana - Jelínek Michaelidesová, Anna - Lukášová, Emilie - Boreyko, A. - Krasavin, E. - Kozubek, Stanislav
Function of chromatin structure and dynamics in DNA damage, repair and misrepair: gamma-rays and protons in action.
Applied Radiation and Isotopes. Roč. 83, SI (2014), s. 128-136. ISSN 0969-8043
R&D Projects: GA MŠMT(CZ) EE2.3.30.0030; GA ČR(CZ) GBP302/12/G157; GA ČR(CZ) GAP302/10/1022; GA ČR(CZ) GBP108/12/G108; GA MŠMT(CZ) LD12039; GA MŠMT(CZ) LD12008
Institutional support: RVO:68081707 ; RVO:61389005
Keywords : DNA double-strand breaks * Higher-order chromatin structure and DSB repair * Formation of chromosomal translocations
Subject RIV: BO - Biophysics; BO - Biophysics (UJF-V)
Impact factor: 1.231, year: 2014

According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams. (C) 2013 Elsevier Ltd. All rights reserved.
Permanent Link: http://hdl.handle.net/11104/0230775