0423125 - ÚEB 2014 RIV US eng J - Journal Article
Nair, J. J. - Rárová, L. - Strnad, Miroslav - Bastida, J. - van Staden, J.
Alkaloids from Boophone haemanthoides (Amaryllidaceae).
Natural Product Communications. Roč. 8, č. 12 (2013), s. 1705-1710. ISSN 1934-578X. E-ISSN 1555-9475
Institutional research plan: CEZ:AV0Z50380511
Keywords : Alkaloid * Amaryllidaceae * Boophone haemanthoides
Subject RIV: CE - Biochemistry
Impact factor: 0.924, year: 2013
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In this study, the South African Amaryllid Boophone haemanthoides was examined for its phytochemical composition and cytotoxicity. In the process eight alkaloid structures, including the new compound distichaminol, were identified in bulb ethanolic extracts. Of the isolates, lycorine and distichamine exhibited strong activities against human acute lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7) and cervical adenocarcinoma (HeLa) cells with IC(50)s ranging from 1.8 to 9.2 mu M.
Permanent Link: http://hdl.handle.net/11104/0229213