Number of the records: 1
Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors
- 1.0423021 - ÚMG 2014 RIV US eng J - Journal Article
Jurášek, M. - Džubák, P. - Sedlák, David - Dvořáková, H. - Hajduch, M. - Bartůněk, Petr - Drasar, P.
Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors.
Steroids. Roč. 78, č. 3 (2013), s. 356-361. ISSN 0039-128X. E-ISSN 1878-5867
R&D Projects: GA MŠMT(CZ) LC06077; GA ČR(CZ) GAP503/11/0616; GA ČR(CZ) GAP304/10/1951
Institutional support: RVO:68378050
Keywords : click chemistry * steroid ribbons * cytotoxic activity * steroid receptor reporter assay * 2,6-bis((1H-1,2,3-triazol-1-yl)methyl)pyridine
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.716, year: 2013
There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using Cu-1 catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular "ribbons" are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities. (C) 2013 Elsevier Inc. All rights reserved.
Permanent Link: http://hdl.handle.net/11104/0229188
Number of the records: 1