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Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart
- 1.0422631 - FGÚ 2014 RIV CZ eng J - Journal Article
Ravingerová, T. - Čarnická, S. - Ledvényiová, V. - Barlaka, E. - Galatou, E. - Chytilová, Anna - Mandíková, Petra - Nemčeková, M. - Adameová, A. - Kolář, František - Lazou, A.
Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart.
Physiological Research. Roč. 62, Suppl.1 (2013), S151-S163. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) 7AMB12SK164
Institutional support: RVO:67985823
Keywords : myocardial ischemia * PPAR activation * metabolic genes * delayed preconditioning * WY-14643
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.487, year: 2013
The results indicate that cardioprotection was associated with remarkably increased expression of PPAR-alpha target genes promoting FA utilization and reduced expression of glucose transporter GLUT-4. Potential non-genomic effects of PPAR-alpha-mediated cardioprotection may involve activation of prosurvival PI3K/Akt pathway and its downstream targets such as eNOS and subsequently reduced apoptosis
Permanent Link: http://hdl.handle.net/11104/0228881
Number of the records: 1