In vivo effect of focused shock waves on tumor tissue and its visualization by fluorescence staining techniques(BIOELECTRICS 2013 )

0422249 - ÚFP 2014 RIV DE eng O - Others
Lukeš, Petr - Zeman, J. - Hoffer, Petr - Poučková, P. - Hosseini, S.H.R. - Akiyama, H. - Šunka, Pavel - Beneš, J.
In vivo effect of focused shock waves on tumor tissue and its visualization by fluorescence staining techniques(BIOELECTRICS 2013 ).
2013
Grant - others:Rada Programu interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M100431203
Program: M
Institutional support: RVO:61389021
Keywords : shock waves * cancer * apoptosis * necrosis
Subject RIV: BL - Plasma and Gas Discharge Physics

Předneseno na:BIOELECTRICS 2013 – 10th International Bioelectrics Symposium,Karlsruhe,16.09.-19.09.2013, In this work we studied in vivo effects of focused tandem shock waves on the tumor tissue using TUNEL and DAPI fluorescence staining techniques. Lewis strain rats with syngeneic sarcoma transplanted into thighs were used as experimental animal model, tandem shock waves were generated by multichannel underwater discharge plasma. Necrotic and apoptotic changes induced by shock waves in tumor tissue were analyzed. The localization and the shape of tissue damage in form of a cone-shaped region correlated with the direction and the shape of shock wave propagation, which was determined in water using high speed shadowgraphy.
Permanent Link: http://hdl.handle.net/11104/0228452