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Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels
- 1.0420960 - FGÚ 2014 RIV GB eng J - Journal Article
Neckář, Jan - Borchert, Gudrun H. - Hloušková, P. - Míčová, P. - Nováková, O. - Novák, F. - Hroch, M. - Papoušek, František - Ošťádal, Bohuslav - Kolář, František
Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels.
Current Pharmaceutical Design. Roč. 19, č. 39 (2013), s. 6880-6889. ISSN 1381-6128. E-ISSN 1873-4286
R&D Projects: GA AV ČR(CZ) IAAX01110901; GA ČR(CZ) GA305/07/0875; GA ČR(CZ) GAP303/12/1162
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : chronic continuous hypoxia * reoxygenation * ischemia/reperfusion * myocardial infarction * potassium channels * oxidative stress
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 3.288, year: 2013
The purpose of the study was to assess the impact of brief daily reoxygenation during adaptation to chronic continuous hypoxia on protective cardiac phenotype. The results suggest that chronic continuous hypoxia is cardioprotective and brief daily reoxygenation blunts its salutary effects, possibly by a mechanism involving oxidative stress and attenuation of the activation of mitochondrial BKCa channels
Permanent Link: http://hdl.handle.net/11104/0227483
Number of the records: 1