Tumor ablation using theranostic nanoparticles

0399446 - FZÚ 2014 US eng A - Abstract
Herynek, V. - Jendelová, Pavla - Turnovcová, Karolína - Pollert, Emil - Veverka, Miroslav - Veverka, Pavel - Jirák, D. - Syková, Eva - Hájek, M.
Tumor ablation using theranostic nanoparticles.
Books of Abstracts. The Sixth Annual World Molecular Imaging Congress. Los Angeles: World Molecular Imaging Society, 2013. s. 1.
[Annual World Molecular Imaging Congress /6./. 18.09.2013-21.09.2013, Savannah, Georgia]
R&D Projects: GA MPO FR-TI3/521
Institutional support: RVO:68378271 ; RVO:68378041
Keywords : perovskite nanoparticles * magnetic resonance imaging * thermoablation
Subject RIV: BO - Biophysics

Theranostic ferromagnetic nanoparticles with low Curie temperature and high relaxivity represent a suitable agent for MRI-guided magnetic fluid hyperthermia applicable in tumor treatment. The method is based on a deposition of stable and nontoxic suspensions of the magnetic nanoparticles inside the tumor followed by an exposure to a high frequency (HF) electromagnetic field. Magnetic hysteresis losses result in local heating by the particles and consequently to apoptosis of cells in their vicinity. The aim of our study was to verify the possibility of tumor thermoablation using the ferromagnetic particles in experimental animals in vivo.
Permanent Link: http://hdl.handle.net/11104/0226723