Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound

0399052 - ÚMCH 2014 RIV US eng J - Journal Article
Carlisle, R. - Choi, J. - Bazan-Peregrino, M. - Laga, R. - Šubr, Vladimír - Kostka, Libor - Ulbrich, Karel - Coussios, C. C. - Seymour, L. W.
Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound.
JNCI-Journal of the National Cancer Institute. Roč. 105, č. 22 (2013), s. 1701-1710. ISSN 0027-8874. E-ISSN 1460-2105
Grant - others:AV ČR(CZ) AP0802
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:61389013
Keywords : cancer * intravenous * adenovirus
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 15.161, year: 2013

Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. Combining drug stealthing and ultrasound-induced cavitation may ultimately enhance the efficacy of a range of powerful therapeutics, thereby improving the treatment of metastatic cancer.
Permanent Link: http://hdl.handle.net/11104/0227733