Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface

0398145 - ÚEM 2014 RIV GB eng J - Journal Article
Čejková, Jitka - Trošan, Peter - Čejka, Čestmír - Lencová, A. - Zajícová, Alena - Javorková, Eliška - Kubinová, Šárka - Syková, Eva - Holáň, Vladimír
Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface.
Experimental Eye Research. Roč. 116, Nov. (2013), s. 312-323. ISSN 0014-4835. E-ISSN 1096-0007
R&D Projects: GA ČR GAP304/11/0653; GA ČR(CZ) GAP301/11/1568
Grant - others:GA UK(CZ) 668012; GA MŠk(CZ) SVV 265211
Institutional research plan: CEZ:AV0Z50390512
Institutional support: RVO:68378041
Keywords : corneal oxidative injury * mesenchymal stem cells * nanofiber scaffolds
Subject RIV: FF - HEENT, Dentistry
Impact factor: 3.017, year: 2013

Nanofiber scaffolds seeded with rabbit bone marrow-derived mesenchymal stem cells (MSCs) were transferred onto the rabbit cornea, damaged with sodium hydroxide, causing oxidative injury in the cornea. MSCs protected the formation of toxic peroxynitrite in the cornea, lowered apoptotic cell death and decreased matrix metalloproteinase and proinflammatory cytokine production. This resulted in reduced corneal inflammation, neovascularization and significantly accelerated corneal healing. key words (3): corneal oxidative injury, mesenchymal stem cells, nanofiber scaffolds.
Permanent Link: http://hdl.handle.net/11104/0225698