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Photodynamic effects of 31 different phthalocyanines on a human keratinocyte cell line

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    0398140 - BÚ 2014 RIV GB eng J - Journal Article
    Jančula, Daniel - Maršálek, Blahoslav - Babica, Pavel
    Photodynamic effects of 31 different phthalocyanines on a human keratinocyte cell line.
    Chemosphere. Roč. 93, č. 6 (2013), s. 870-874. ISSN 0045-6535. E-ISSN 1879-1298
    R&D Projects: GA TA ČR TA01010356
    Grant - others:European Commission(XE) FP/2007-2013 no.2SGA2858
    Program: FP/2007-2013
    Institutional support: RVO:67985939
    Keywords : phthalocyanines * photodynamics * toxicity
    Subject RIV: EF - Botanics
    Impact factor: 3.499, year: 2013

    We have found light dependent toxicity of different groups of Pcs on HaCaT cells. The most pronounced toxicity was elicited by Pcs with high positive densities at peripheral parts of substituent groups under illumination by white light. EC50 values for HaCaT cells are an order or two orders of magnitude higher than concentrations considered for management purposes in aquaculture, which indicate the safety of such applications for human or animal skin cells after the exposition. Nevertheless, more research including risk assessment should be done to confirm such conclusions.
    Permanent Link: http://hdl.handle.net/11104/0225677

     
     
Number of the records: 1  

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