Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension

0397967 - FGÚ 2014 RIV GB eng J - Journal Article
Radošinská, J. - Bačová, B. - Knezl, V. - Beňová, T. - Žurmanová, J. - Soukup, Tomáš - Arnoštová, P. - Slezák, J. - Goncalvesová, E. - Tribulová, N.
Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.
Journal of Hypertension. Roč. 31, č. 9 (2013), s. 1876-1885. ISSN 0263-6352. E-ISSN 1473-5598
R&D Projects: GA ČR(CZ) GA304/08/0256; GA MŠMT(CZ) 7AMB12SK158
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : hypertension * omega-3 polyunsaturated fatty acids * ventricular fibrillation * sinus rhythm restoration * myocardial connexin-43 * protein kinase C * myosin heavy chain
Subject RIV: EA - Cell Biology
Impact factor: 4.222, year: 2013

Omega-3 intake significantly reduced cardiovascular risk factors, suppressed inducible VF and facilitated SRR in hypertensive rats. Treatment attenuated lateralization and internalization of Cx43, suppressed elevated Cx43mRNA but enhanced total Cx43 protein expression and/or its functional phosphorylated forms as well as the expression cardio-protective PKC-epsilon and suppressed pro-apoptotic PKC-delta isoform. Moreover, the omega-3 diet normalized MyHC profiles in SHR at early stage of disease and old nonhypertensive rats, but failed to do so in old SHR at late stage of disease
Permanent Link: http://hdl.handle.net/11104/0225559