Single-step synthesis of a new series of meso di-Mannich bases from the cyclic aminal (2S,7R,11S,16R)-1,8,10,17-tetraazapentacyclo [8.8.1.1..sup.8,17./sup.0..sup.2,7./sup.0.sup.11,16./sup.]icosane and p-substituted phenols

0397517 - FZÚ 2014 RIV GB eng J - Journal Article
Rivera, A. - Quiroga, D. - Ríos-Motta, J. - Eigner, V. - Dušek, Michal
Single-step synthesis of a new series of meso di-Mannich bases from the cyclic aminal (2S,7R,11S,16R)-1,8,10,17-tetraazapentacyclo [8.8.1.1.^8,170.^2,70^11,16]icosane and p-substituted phenols.
Chemistry Central Journal. Roč. 7, JUN (2013), s. 100. ISSN 1752-153X. E-ISSN 1752-153X
Institutional support: RVO:68378271
Keywords : p-substituted phenols * Mannich bases * single-step synthesis * Jana2006
Subject RIV: CC - Organic Chemistry
Impact factor: 1.663, year: 2013

The results presented herein show that the cyclic aminal (2S,7R,11S,16R)-1,8,10,17-tetraazapentacyclo [8.8.1.1.8,170.2,7011,16]icosane(6), derived from cis-(meso)-1,2-diaminocyclohexane and formaldehyde, is a suitable substrate for the preparation of a series of cis-meso Mannich bases such as 8a-l by reaction with p-substituted phenols 7a-l in basic media. These compounds are valuable synthetic products and may find application in asymmetric catalysis
Permanent Link: http://hdl.handle.net/11104/0225127