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The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects
- 1.0397075 - ÚEM 2014 RIV DE eng J - Journal Article
Vaněček, Václav - Klíma, K. - Kohout, A. - Foltán, R. - Jiroušek, Ondřej - Šedý, Jiří - Štulík, J. - Syková, Eva - Jendelová, Pavla
The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects.
European Spine Journal. Roč. 22, č. 12 (2013), s. 2777-2786. ISSN 0940-6719. E-ISSN 1432-0932
R&D Projects: GA ČR GAP304/10/0320; GA MZd(CZ) NT13477
Institutional support: RVO:68378041 ; RVO:68378297 ; RVO:67985823
Keywords : vertebral body defect * mesenchymal stem cells * hydroxyapatite scaffold
Subject RIV: FH - Neurology; FI - Traumatology, Orthopedics (UTAM-F); FI - Traumatology, Orthopedics (FGU-C)
Impact factor: 2.473, year: 2013
The safety and efficacy of a composite bioartificial graft based on a hydroxyapatite bone scaffold (CEM-OSTETIC®) combined with human mesenchymal stem cells (MSCs) was evaluated in a rat model of vertebral body defects. Significant effect on the formation of new bone tissue in the defect a reduced inflammatory reaction was detected after combination of 5 mil MSC and scaffold. No substantial pathological changes or tumor formation after graft implantation were observed.
Permanent Link: http://hdl.handle.net/11104/0227057
Number of the records: 1