Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis

0396937 - FGÚ 2014 RIV NL eng J - Journal Article
De la Rosa, A. J. - Domínguez, J. N. - Sedmera, D. - Šaňková, Barbora - Hove-Madsen, L. - Franco, D. - Aránega, A. E.
Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.
Cardiovascular Research. Roč. 98, č. 3 (2013), s. 504-514. ISSN 0008-6363. E-ISSN 1755-3245
R&D Projects: GA ČR(CZ) GA304/08/0615; GA ČR(CZ) GAP302/11/1308; GA ČR(CZ) GD204/09/H084; GA ČR(CZ) GA13-12412S
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : ion channels * Long-QT syndrome * sudden death * cardiac hypertrophy
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 5.808, year: 2013

Early sodium channel remodelling secondary to IKs blockage in a mouse model of LQTS leading to morphological and functional anomalies in the developing VCS and cardiac hypertrophy. These results provide new insights into the mechanisms underlying foetal and neonatal cardiac electrophysiological disorders, which might help understand how molecular, functional, and morphological alterations are linked to clinical pathologies such as cardiac congenital anomalies, arrhythmias, and perinatal sudden death
Permanent Link: http://hdl.handle.net/11104/0224587