Meta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility

0396320 - ÚEM 2014 RIV US eng J - Journal Article
Picelli, S. - Bermejo, J. L. - Chang-Claude, J. - Hoffmeister, M. - Fernandez-Rozadilla, C. - Carracedo, A. - Castells, A. - Castellví-Bel, S. - Naccarati, Alessio - Pardini, Barbara - Vodičková, Ludmila - Müller, H. - Talseth-Palmer, B. A. - Stibbard, G. - Peterlongo, P. - Nici, C. - Veneroni, S. - Li, L. - Casey, G. - Tenesa, A. - Farrington, S.M. - Tomlinson, I. - Moreno, V. - van Wezel, T. - Wijnen, J. - Dunlop, M. - Radice, P. - Scott, R. J. - Vodička, Pavel - Ruiz-Ponte, C. - Brenner, H. - Buch, S. - Völzke, H. - Hampe, J. - Schafmayer, C. - Lindblom, A.
Meta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility.
PLoS ONE. Roč. 8, č. 9 (2013), e72091. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR GAP304/10/1286; GA ČR GA310/07/1430
Institutional support: RVO:68378041
Keywords : colerectal cancer * The EPICOLON Consortium
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.534, year: 2013

In the last four years, Genome-Wide Association Studies (GWAS) have identified sixteen low-penetrance polymorphisms on fourteen different loci associated with colorectal cancer (CRC). The results from the present large, multicenter study illustratethe possibility of decreasing effect sizes with increasing samples sizes. Phenotypic heterogeneity, differential environmental exposures, and population specific linkage disequilibrium patterns may explain the observed difference of genetic effects between Sweden and the other investigated cohorts.
Permanent Link: http://hdl.handle.net/11104/0224138