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Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides
- 1.0396257 - ÚOCHB 2014 RIV GB eng J - Journal Article
Tichý, Michal - Pohl, Radek - Tloušťová, Eva - Weber, Jan - Bahador, G. - Lee, Y. J. - Hocek, Michal
Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides.
Bioorganic & Medicinal Chemistry. Roč. 21, č. 17 (2013), s. 5362-5372. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : nucleosides * pyrimido[4,5-b]indoles * Suzuki and Stille cross-coupling * anti-dengue virus activity
Subject RIV: CC - Organic Chemistry
Impact factor: 2.951, year: 2013
Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses.
Permanent Link: http://hdl.handle.net/11104/0224106
Number of the records: 1