Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances

0395423 - MBÚ 2014 RIV GB eng J - Journal Article
Mrázek, Hynek - Weignerová, Lenka - Bojarová, Pavla - Novák, Petr - Vaněk, Ondřej - Bezouška, Karel
Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances.
Biotechnology Advances. Roč. 31, č. 1 (2013), s. 17-37. ISSN 0734-9750. E-ISSN 1873-1899
R&D Projects: GA ČR GA303/09/0477; GA ČR GD305/09/H008; GA ČR GAP207/10/0321; GA MŠMT(CZ) 7E11011; GA MŠMT(CZ) LD13041
Institutional support: RVO:61388971
Keywords : Cellular factories * Complex carbohydrates * Glycodrugs
Subject RIV: CE - Biochemistry
Impact factor: 8.905, year: 2013

The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species
Permanent Link: http://hdl.handle.net/11104/0223446