Chelating polymeric particles intended for the therapy of Wilson’s disease

0395188 - ÚMCH 2014 RIV NL eng J - Journal Article
Škodová, Michaela - Kučka, Jan - Vetrík, Miroslav - Skopal, Jan - Walterová, Zuzana - Sedláček, Ondřej - Štěpánek, Petr - Mattová, J. - Poučková, P. - Urbánek, P. - Hrubý, Martin
Chelating polymeric particles intended for the therapy of Wilson’s disease.
Reactive and Functional Polymers. Roč. 73, č. 11 (2013), s. 1426-1431. ISSN 1381-5148. E-ISSN 1873-166X
R&D Projects: GA ČR GAP304/12/0950; GA ČR GA13-08336S
Institutional support: RVO:61389013
Keywords : Wilson’s disease * polymer beads * copper metabolism
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 2.822, year: 2013

Wilson’s disease is a genetic disorder that leads to a high accumulation of copper in multiple organs with subsequent toxic effects. In this paper, a gentle therapy to eliminate harmful copper concentrations in patients with Wilson’s disease is proposed using an oral administration of insoluble polymeric sorbents containing selective chelating groups for copper(II). The sorbents contained triethylenetetramine, N,N-di(2-pyridylmethyl)amine, 8-hydroxyquinoline or 8-hydroxyquinoline-5-sulfonic acid chelating groups bound to a methacrylate-based macroporous support. Nearly quantitative copper(II) uptake within minutes was achieved in buffers modeling the pH range present in the gastric environment (pH 2.0 and 4.0). The sorbents demonstrated chelating selectivity for copper(II) against zinc(II) with ratios of up to 1321. The sorbents demonstrated sufficient stability of the copper complexes against rechelation using studies in a model environment for the small intestine (the presence of chelating amino acids, pH 6.8).
Permanent Link: http://hdl.handle.net/11104/0226851