Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying

0394941 - ÚMCH 2014 RIV GB eng J - Journal Article
Vetrík, Miroslav - Přádný, Martin - Kobera, Libor - Šlouf, Miroslav - Rabyk, Mariia - Pospíšilová, Aneta - Štěpánek, Petr - Hrubý, Martin
Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying.
RSC Advances. Roč. 3, č. 35 (2013), s. 15282-15289. E-ISSN 2046-2069
R&D Projects: GA ČR GAP108/10/1560; GA ČR GA202/09/2078
Grant - others:AV ČR(CZ) M200501201
Program: M
Institutional support: RVO:61389013
Keywords : glycogen * nanofibres * poly(ethyl cyanoacrylate)
Subject RIV: BO - Biophysics
Impact factor: 3.708, year: 2013

We describe a new biopolymer-based nanofibrous material possibly suitable for tissue engineering prepared by an environment-friendly organic solvent-free method. Glycogen, a biodegradable hyperbranched D-glucose polymer, comes from renewable resources and is normally present in man. It forms nanofibres by simple freeze-drying from aqueous solutions with concentration less than 0.5%. However, the architecture of the freeze-dried material depends on the starting biopolymer concentration within the tested range 0.1–5 wt%; in particular higher concentrations produce porous sponge-like structures with communicating pores. Because of the solubility of glycogen in water, nanofibres were modified by solvent-free grafting biodegradable poly(ethyl cyanoacrylate) from vapor phase. Exposing glycogen nanofibres to vapors of ethyl cyanoacrylate only slightly changed the material architecture while producing a water-insoluble biodegradable material with glycogen-to-poly(ethyl cyanoacrylate) ratio depending on the polymerization time. The material was proven to be hydrolytically degradable over the course of several months.
Permanent Link: http://hdl.handle.net/11104/0223534