New insight into transcription of human endogenous retroviral elements

0394696 - ÚMG 2013 RIV NL eng J - Journal Article
Pačes, Jan - Huang, Y.T. - Pačes, Václav - Rídl, Jakub - Chang, C.M.
New insight into transcription of human endogenous retroviral elements.
New Biotechnology. Roč. 30, č. 3 (2013), s. 314-318. ISSN 1871-6784. E-ISSN 1876-4347
R&D Projects: GA ČR GCP305/10/J052
Grant - others:Chang Gung Memorial Hospital(TW) CMRPD170233; NSCNHRI Taiwan(TW) NSC 97-2314-B-182-001-MY2; NSCNHRI Taiwan(TW) NSC 99-2314-B-182-024-MY3; NSCNHRI Taiwan(TW) NSC 99-2923-B-182-001-MY3
Institutional support: RVO:68378050
Keywords : HERV * transcription * tissue-specific
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.106, year: 2013

It is generally assumed that human endogenous retroviral elements (HERVs) belong to the class of genomic repetitive nucleotide sequences often called ‘junk DNA’. These elements were categorized to families, and members of some of these families (e.g. HERV-H, HERV-W and HERV-K) were shown to be transcribed. These transcriptions were associated with several severe diseases such as mental disorders, AIDS, autoimmune diseases and cancer. In this review we discuss several bioinformatics strategies for genome-wide scan of HERVs transcription using high-throughput RNA sequencing on several platforms. We show that many more HERVs than previously described are transcribed to various levels and we discuss possible implications of these transcriptions.
Permanent Link: http://hdl.handle.net/11104/0222898