Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery

0394384 - ÚMCH 2015 RIV US eng J - Journal Article
Shubhra, Q. T. H. - Macková, Hana - Horák, Daniel - Fodor-Kardos, A. - Tóth, J. - Gyenis, J. - Feczkó, T.
Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery.
E-Polymers. Roč. 13, č. 1 (2013), s. 310-318. ISSN 1618-7229. E-ISSN 1618-7229
R&D Projects: GA AV ČR(CZ) KAN401220801; GA MŠMT 7E12054
EU Projects: European Commission(XE) 259796 - DIATOOLS
Institutional support: RVO:61389013
Keywords : magnetic * PLGA * particles
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 0.330, year: 2013

Two types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible ³-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles. The nanoparticles, together with human serum albumin (HSA) serving as a model for a protein-type drug, were then incorporated in poly(lactide-co-glycolide) (PLGA) particles using double emulsion solvent evaporation technique. Morphology, size and particle size distribution of the resulting particles was analyzed by electron microscopy and dynamic light scattering. Iron oxide and HSA encapsulating efficiency was determined by Prussian Blue staining and micro-BCA assay, respectively.
Permanent Link: http://hdl.handle.net/11104/0222824