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Novel antimicrobial peptides
- 1.0394191 - ÚOCHB 2014 RIV eng P - Patent Document
Monincová, Lenka - Čeřovský, Václav - Slaninová, Jiřina - Hovorka, Oldřich - Cvačka, Josef - Voburka, Zdeněk - Fučík, Vladimír - Borovičková, Lenka
Novel antimicrobial peptides.
2013. Owner: Ústav organické chemie a biochemie Akademie věd ČR, v. v. i. Date of the patent acceptance: 06.03.2013. Patent Number: EP2396020
R&D Projects: GA ČR GA203/08/0536
Institutional research plan: CEZ:AV0Z40550506
Keywords : antimicrobial peptides * bee venom * hemolytic activity * NMR spectroscopy * CD spectroscopy
Subject RIV: CE - Biochemistry
http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20130306&DB=EPODOC&locale=en_EP&CC=EP&NR=2396020B1&KC=B1&ND=4
The invention involves two novel peptides of the formulas H-Gly -Met-Trp -Ser-Lys-Ile-Leu-Gly -His-Leu-Ile-Arg -NH2 (I) and H-Gly -Lys-Trp -Met-Ser-Leu-Leu-Lys -His-Ile-Leu-Lys-NH2 (II) isolated from venom reservoirs of primitively eusocial bees Halictus sexcintus and their synthetic analogs possessing biological effects, prepared by the substitution of an amino acid in position 4, 11 or 12 of formula (I) or in position 4 of formula (II) by an amino acid lysine. Described is also their usage for the preparation of medicaments for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment.
Permanent Link: http://hdl.handle.net/11104/0222491
Number of the records: 1