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Monotopic modifications derived from in vitro glycation of albumin with ribose
- 1.0394058 - FGÚ 2014 RIV DE eng J - Journal Article
Pataridis, Statis - Šťastná, Zdeňka - Sedláková, Pavla - Mikšík, Ivan
Monotopic modifications derived from in vitro glycation of albumin with ribose.
Electrophoresis. Roč. 34, č. 12 (2013), s. 1757-1763. ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA ČR(CZ) GAP206/12/0453; GA ČR(CZ) GA203/08/1428
Institutional support: RVO:67985823
Keywords : advanced glycation end product (AGE) * albumin * CE-MS * glycation * LC-MS/MS
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 3.161, year: 2013
The glycation of albumins (HSA and BSA) was studied by nano-LC coupled to a QTOF mass spectrometer. Non-enzymatic in vitro reaction products between albumin and ribose were identified. Besides well-known carboxymethyl lysine, new modifications were determined –creating mass shifts of 78 and 218. The origin of the first modification is discussed and its possible structure is presented. Another mass shift of 132 belonged to a Schiff base
Permanent Link: http://hdl.handle.net/11104/0222379
Number of the records: 1