Excited state dynamics of DNA bases

0393488 - ÚOCHB 2014 RIV GB eng J - Journal Article
Kleinermanns, K. - Nachtigallová, Dana - de Vries, M. S.
Excited state dynamics of DNA bases.
International Reviews in Physical Chemistry. Roč. 32, č. 2 (2013), s. 308-342. ISSN 0144-235X. E-ISSN 1366-591X
R&D Projects: GA ČR GAP208/12/1318
Grant - others:National Science Foundation(US) CHE-0911564; NASA(US) NNX12AG77G; Deutsche Forschungsgemeinschaft(DE) SFB 663; Deutsche Forschungsgemeinschaft(DE) KI 531-29
Institutional support: RVO:61388963
Keywords : DNA bases * nucleobases * excited state * dynamics * computations * gas phase * conical intersections
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 4.920, year: 2013

Biochemical reactions are subject to the particular environmental conditions of planet earth, including solar irradiation. How DNA responds to radiation is relevant to human health because radiation damage can affect genetic propagation and lead to cancer and is also important for our understanding of how life on earth developed. A reductionist approach to unravelling the detailed photochemistry seeks to establish intrinsic properties of individual DNA building blocks, followed by extrapolation to larger systems, to incorporate interactions between the building blocks and the role of the biomolecular environment. Advances in both experimental and computational techniques have lead to increasingly detailed insights in the excited state dynamics of DNA bases in isolation as well as the role of the solvent and intermolecular interactions. This review seeks to summarise current findings and understanding.
Permanent Link: http://hdl.handle.net/11104/0222224