Tissue-Specific Peroxisome Proliferator Activated Receptor Gamma Expression and Metabolic Effects of Telmisartan

0392963 - FGÚ 2014 RIV US eng J - Journal Article
Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Landa, Vladimír - Kazdová, L. - Pravenec, Michal - Kurtz, T. W.
Tissue-Specific Peroxisome Proliferator Activated Receptor Gamma Expression and Metabolic Effects of Telmisartan.
American Journal of Hypertension. Roč. 26, č. 6 (2013), s. 829-835. ISSN 0895-7061. E-ISSN 1941-7225
R&D Projects: GA ČR(CZ) GAP303/10/0505; GA MŠMT(CZ) LH11049; GA MŠMT(CZ) LL1204; GA MŠMT(CZ) 7E10067
Institutional support: RVO:67985823
Keywords : telmisartan * metabolic effects * tissue-specific Pparg knockout mice
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 3.402, year: 2013

We found that knockout of Pparg in fat tissue greatly impaired the ability of telmisartan to increase adiponectin levels and to enhance sensitivity to insulin stimulated glucose incorporation into adipose tissue lipids. In contrast, muscle-specific Pparg knockout had relatively little or no impact on the ability of telmisartan to increase adiponectin levels or affect glucose metabolism either in fat or muscle. These findings provide compelling evidence that the ability of telmisartan to increase adiponectin levels and stimulate glucose utilization in adipose tissue may depend on the presence of PPARG in fat
Permanent Link: http://hdl.handle.net/11104/0221759