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Spectroelectrochemistry of Flavonolignans and their DNA-binding Copper Complexes

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    0392887 - ÚFCH JH 2014 RIV CZ eng C - Conference Paper (international conference)
    Sokolová, Romana - Kubala, M. - Vavříková, E. - Ulrichová, J. - Křen, Vladimír - Vacek, J.
    Spectroelectrochemistry of Flavonolignans and their DNA-binding Copper Complexes.
    XIII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. Brno: Masarykova Universita, 2013, s. 161-162. ISBN 978-80-7375-757-1.
    [Pracovní setkání fyzikálních chemiků a elektrochemiků /13./. Brno (CZ), 29.05.2013-30.05.2013]
    Grant - others:Rada Programu interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M200401201
    Program: M
    Institutional support: RVO:61388955 ; RVO:61388971
    Keywords : spectroelectrochemistry * flavonolignans * copper complexes
    Subject RIV: CG - Electrochemistry

    The oxidation of flavonolagnan silybin and its selected derivatives was studied on glassy carbon electrode in aqueous environment by means of cyclic voltammetry, in situ UV/VIS spectroelectrochemistry and absorption spectrometry. The oxidation mechanism of flavonolignans and their complexion with copper was investigated under anaerobic conditions. The acquired results were interpreted in context of protective (antioxidant) and DNA-binding (prooxidant) properties of flavonolignans and their transition metal complexes.
    Permanent Link: http://hdl.handle.net/11104/0221660

     
     
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