Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex

0392769 - BC 2014 RIV GB eng J - Journal Article
Hashimi, Hassan - Zimmer, S.L. - Ammerman, M. L. - Read, L. K. - Lukeš, Julius
Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.
Trends in Parasitology. Roč. 29, č. 2 (2013), s. 91-99. ISSN 1471-4922. E-ISSN 1471-5007
R&D Projects: GA ČR GAP305/12/2261; GA ČR GA204/09/1667
Institutional support: RVO:60077344
Keywords : kinetoplastida * trypanosome * RNA editing * protein complexes * RECC * MRB1
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 6.217, year: 2013
http://www.sciencedirect.com/science/article/pii/S1471492212001985

Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events.
Permanent Link: http://hdl.handle.net/11104/0221719