Redox state of p63 and p73 core domains regulates sequence-specific DNA binding

0392682 - BFÚ 2014 RIV US eng J - Journal Article
Tichý, Vlastimil - Navrátilová, Lucie - Adámik, Matěj - Fojta, Miroslav - Brázdová, Marie
Redox state of p63 and p73 core domains regulates sequence-specific DNA binding.
Biochemical and Biophysical Research Communications. Roč. 433, č. 4 (2013), s. 445-449. ISSN 0006-291X. E-ISSN 1090-2104
R&D Projects: GA ČR(CZ) GAP301/10/2370; GA ČR(CZ) GAP301/11/2076
Institutional support: RVO:68081707
Keywords : TUMOR-SUPPRESSOR P53 * RESPONSE ELEMENTS * SUPERCOILED DNA
Subject RIV: BO - Biophysics
Impact factor: 2.281, year: 2013

Cysteine oxidation and covalent modification of redox sensitive transcription factors including p53 are known, among others, as important events in cell response to oxidative stress. All p53 family proteins p53, p63 and p73 act as stress-responsive transcription factors. Oxidation of p53 central DNA binding domain destroys its structure and abolishes its sequence-specific binding by affecting zinc ion coordination at the protein-DNA interface. Proteins p63 and p73 can bind the same response elements as p53 but exhibit distinct functions. Moreover, all three proteins contain highly conserved cysteines in central DNA binding domain suitable for possible redox modulation.
Permanent Link: http://hdl.handle.net/11104/0221501