Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production

0392583 - BFÚ 2014 RIV GB eng J - Journal Article
Papežíková, Ivana - Pekarová, Michaela - Kolářová, Hana - Klinke, A. - Lau, D. - Baldus, S. - Lojek, Antonín - Kubala, Lukáš
Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production.
Free Radical Research. Roč. 47, č. 2 (2013), s. 82-88. ISSN 1071-5762. E-ISSN 1029-2470
R&D Projects: GA ČR(CZ) GA524/08/1753; GA ČR(CZ) GP204/07/P539
Grant - others:GA MŠk(CZ) ED1.100/02/0123
Institutional research plan: CEZ:AV0Z50040702
Institutional support: RVO:68081707
Keywords : CORONARY-ARTERY-DISEASE * CHRONIC HEART-FAILURE * SUPEROXIDE-DISMUTASE
Subject RIV: BO - Biophysics
Impact factor: 2.989, year: 2013

Endothelial dysfunction characterized by decreased nitric oxide (NO) bioavailability is the first stage of coronary artery disease. It is known that one of the factors associated with an increased risk of coronary artery disease is a high plasma level of uric acid. However, causative associations between hyperuricaemia and cardiovascular risk have not been definitely proved. In this work, we tested the effect of uric acid on endothelial NO bioavailability. Electrochemical measurement of NO production in acetylcholine-stimulated human umbilical endothelial cells (HUVECs) revealed that uric acid markedly decreases NO release. This finding was confirmed by organ bath experiments on mouse aortic segments. Uric acid dose-dependently reduced endothelium-dependent vasorelaxation.
Permanent Link: http://hdl.handle.net/11104/0221398