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Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
- 1.0392100 - FGÚ 2014 RIV NL eng J - Journal Article
Langley, S. R. - Bottolo, L. - Kuneš, Jaroslav - Zicha, Josef - Zídek, Václav - Hubner, N. - Cook, S.A. - Pravenec, Michal - Aitman, T. J. - Petretto, E.
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.
Cardiovascular Research. Roč. 97, č. 4 (2013), s. 653-665. ISSN 0008-6363. E-ISSN 1755-3245
R&D Projects: GA MŠMT(CZ) LH11049; GA MŠMT(CZ) LL1204; GA MŠMT(CZ) 7E10067
Institutional support: RVO:67985823
Keywords : integrative genomics * expression QTLs * time series analysis * trans-acting regulation * genome-wide association studies
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.808, year: 2013
We showed extensive conservation of trans-regulated genes and their master regulators between rat and human hypertension. These findings reveal that small-effect genes associated with hypertension by human GWAS are likely to exert their action through coordinate regulation of pathogenic pathways
Permanent Link: http://hdl.handle.net/11104/0221065
Number of the records: 1