How insulin engages its primary binding site on the insulin receptor

0391760 - ÚOCHB 2014 RIV GB eng J - Journal Article
Menting, J. G. - Whittaker, J. - Margetts, M. B. - Whittaker, L. J. - Kong, G. K. W. - Smith, B. J. - Watson, C. J. - Žáková, Lenka - Kletvíková, Emília - Jiráček, Jiří - Chan, S. J. - Steiner, D. F. - Dodson, G. G. - Brzozowski, A. M. - Weiss, M. A. - Ward, C. W. - Lawrence, M. C.
How insulin engages its primary binding site on the insulin receptor.
Nature. Roč. 493, č. 7431 (2013), s. 241-245. ISSN 0028-0836. E-ISSN 1476-4687
R&D Projects: GA ČR GPP207/11/P430
Institutional support: RVO:61388963
Keywords : insulin * receptor * complex * crystal structure
Subject RIV: CE - Biochemistry
Impact factor: 42.351, year: 2013

Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Here we present the first view, to our knowledge, of the interaction of insulin with its primary binding site on the insulin receptor, on the basis of four crystal structures of insulin bound to truncated insulin receptor constructs.
Permanent Link: http://hdl.handle.net/11104/0220731