Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen

0391725 - FGÚ 2014 RIV GB eng J - Journal Article
Jabůrek, Martin - Ježek, Jan - Zelenka, Jaroslav - Ježek, Petr
Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen.
International Journal of Biochemistry and Cell Biology. Roč. 45, č. 4 (2013), s. 816-825. ISSN 1357-2725. E-ISSN 1878-5875
R&D Projects: GA ČR(CZ) GAP302/10/0346; GA ČR(CZ) GPP303/11/P320; GA MŠMT(CZ) ME09018
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : mitochondrial uncoupling protein UCP2 * mitochondrial phospholipase A(2) isoform gamma * mitochondrial oxidative stress attenuation * fatty acid * antioxidant mechanism
Subject RIV: ED - Physiology
Impact factor: 4.240, year: 2013

Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of action and the physiological significance of UCP2 activity remain controversial. Here we tested the hypothesis that UCP2 provides feedback downregulation of oxidative stress in vivo via synergy with an H2O2-activated mitochondrial calcium-independent phospholipase A2 (mt-iPLA2). In this article we demonstarte for the first time that UCP2, functional due to fatty acids released by redox-activated mt-iPLA2gamma, suppresses mitochondrial superoxide production by its uncoupling action. In conclusion, H2O2-activated mt-iPLA2gamma and UCP2 act in concert to protect against oxidative stress
Permanent Link: http://hdl.handle.net/11104/0220691