Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)

0391719 - FGÚ 2014 RIV GB eng J - Journal Article
Folbergrová, Jaroslava - Ješina, Pavel - Nůsková, Hana - Houštěk, Josef
Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2).
International Journal of Developmental Neuroscience. Roč. 31, č. 2 (2013), s. 123-130. ISSN 0736-5748. E-ISSN 1873-474X
R&D Projects: GA ČR(CZ) GA309/08/0292; GA ČR(CZ) GAP303/10/0999; GA MŠMT(CZ) LL1204
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : immature rats * DL-homocysteic acid-induced seizures * long periods of survival following the seizures * the antioxidant enzyme activities * protein levels of SOD * upregulation of SOD2 following the seizures
Subject RIV: FH - Neurology
Impact factor: 2.918, year: 2013

In control animals activities of individual antioxidant enzymes revealed different changes during the studied postnatal period (PD12-PD47).In animals in which seizures were induced by DL-homocysteic acid, the activity of total SOD, SOD1 and particularly SOD2 significantly increased at 20 h and 6 days of survival following the seizures.Upregulation of SOD2 was also confirmed in mitochondria at the protein level by immunoblotting.The activities of other antioxidant enzymes did not differ from the appropriate controls. The findings suggest that antioxidant defense in brain of immature animals during seizures is limited and may thus contribute to the occurrence of oxidative stress
Permanent Link: http://hdl.handle.net/11104/0220716