Number of the records: 1
Cancer therapy by targeted polymeric drugs evokes activation of the host´s immune system
- 1.0390561 - MBÚ 2013 GB eng A - Abstract
Říhová, Blanka - Šírová, Milada - Kovář, Marek - Etrych, Tomáš - Šubr, Vladimír - Strohalm, Jiří - Chytil, Petr - Ulbrich, Karel
Cancer therapy by targeted polymeric drugs evokes activation of the host´s immune system.
Immunology 137. Glasgow: Blackwell Publishing Ltd, 2012. Roč. 137, č. 1 (2012), s. 803-803. ISSN 0019-2805. E-ISSN 1365-2567.
[European Congress of Immunology – ECI 2012. 05.09.2012-08.09.2012, Glasgow]
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : cancer * doxorubicin * tumor
Subject RIV: EC - Immunology
http://onlinelibrary.wiley.com/doi/10.1111/imm.12003_2/pdf
The possibility was tested to induce potent and long-lasting tumor-specific immunity during the treatment of experimental cancer with targeted water-soluble polymer based on N-(2-hydroxypropyl) methacrylamide (HPMA) containing doxorubicin. The drug (doxorubicin; DOX) was bound to its polymeric carrier through low pH-sensitive hydrazone bond from which drug is released only intracellularly in endosomes and lysosomes
Permanent Link: http://hdl.handle.net/11104/0219437
Number of the records: 1