Squamous Cell Carcinoma

0390206 - ÚMG 2013 RIV HR eng M - Monography Chapter
Králová, Jarmila - Záruba, K. - Řezanka, P. - Poučková, P. - Veverková, L. - Král, V.
Combined therapy for squamous carcinoma cells: application of porphyrin-alkaloid modified gold nanoparticles.
Squamous Cell Carcinoma. Rijeka: InTech, 2012 - (Li, X.), s. 93-118. ISBN 978-953-51-0024-9
R&D Projects: GA ČR GA203/09/1311; GA ČR(CZ) GAP303/11/1291; GA MŠMT(CZ) LC06077
Grant - others:MŠMT(CZ) LC512
Program: LC
Institutional research plan: CEZ:AV0Z50520514
Keywords : photodynamic therapy * photosensitizer * cancer therapy
Subject RIV: EB - Genetics ; Molecular Biology

Photodynamic therapy (PDT) is an established and useful modality for the clinical non-invasive treatment of cancer. This therapy requires a photosensitizing agent(photosensitizer) selectively taken up by tumor cells, visible light, and molecular oxygen to generate highly reactive oxygen species (ROS),which ultimately cause tumor destruction.The specificity achieved from drug uptake selectivity combined with light targeting makes PDT an appealing approach. PDT consists of three phases:excitation of photosensitizers (PS) by light, production of ROS, and induction of cell death (Triesscheijn et al., 2006). In the first phase, irradiated light of a suitable wavelength, typically visible or near-infrared, excites the PS molecules. The light is generally selected to correspond with the maximum absorption wavelength of the PS. The PS molecules then absorb light energy and change to an excited singlet state. These excited molecules can fall back to their native state with emission of fluorescence. Thus, all PS molecules are also examples of fluorescent molecules. On the other hand, the molecules also have the ability to undergo an electron spin conversion to their triplet state followed by the transfer of this energy to oxygen molecules or to other substrate molecules in the surroundings which then react with oxygen.
Permanent Link: http://hdl.handle.net/11104/0219410