Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice

0389996 - FGÚ 2013 RIV GB eng J - Journal Article
Matěj, R. - Olejár, Tomáš - Janoušková, O. - Holada, K.
Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice.
Journal of General Virology. Roč. 93, č. 9 (2012), s. 2057-2061. ISSN 0022-1317. E-ISSN 1465-2099
Institutional support: RVO:67985823
Keywords : protease-activated receptor (PAR2) * scrapie * neurodegenerative disorders
Subject RIV: FN - Epidemiology, Contagious Diseases ; Clinical Immunology
Impact factor: 3.127, year: 2012

Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2/) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2/ mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly, no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2/mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis
Permanent Link: http://hdl.handle.net/11104/0218882