Thermal decomposition study and biological characterization of zinc(II) 2-chlorobenzoate complexes with bioactive ligands

0389737 - ÚMCH 2013 RIV HU eng J - Journal Article
Findoráková, L. - Györyová, K. - Hudecová, D. - Mudroňová, D. - Kovářová, Jana - Homzová, K. - Nour El-Dien, F. A.
Thermal decomposition study and biological characterization of zinc(II) 2-chlorobenzoate complexes with bioactive ligands.
Journal of Thermal Analysis and Calorimetry. Roč. 111, č. 3 (2013), s. 1771-1781. ISSN 1388-6150. E-ISSN 1588-2926.
[Central and Eastern European Conference on Thermal Analysis and Calorimetry /1./ - CEEC-TAC1. Craiova, 07.09.2011-10.09.2011]
Institutional research plan: CEZ:AV0Z40500505
Keywords : zinc * 2-chlorobenzoate * thermal
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.206, year: 2013

New zinc(II) 2-chlorobenzoates of general formula [Zn(2-ClC6H4COO)2(L)2] (where L = caffeine - caf, urea - u, methyl-3-pyridylcarbamate - mpc, phenazone - phen, theophylline - thp) were synthesised and characterised by elemental analysis and IR spectroscopy. The thermal behaviour of the complexes was studied by TG/DTG and DTA methods in nitrogen and in air atmosphere. During the thermal decomposition of the studied compounds the release of organic ligands take place followed by the decomposition of 2-chlorobenzoate anion. The volatile decomposition intermediates were proved by mass spectrometry. Zinc oxide was found as the final product of the thermal decomposition performed up to 1000 K. The antimicrobial activity of the zinc(II) complexes against various strains of bacteria, yeasts and filamentous fungi has been investigated. It was found that the prepared compounds retarded the growth of Staphylococcus aureus, Escherichia coli, Candida albicans, Rhizopus oryzae and Microsporum gypseum, respectively. The most resistant to all tested compounds was probiotic strain of Lactobacillus plantarum. The presence of zinc and ligands in the prepared compounds increased the inhibitory effect compared to sodium salt of prepared compounds and free ligands alone.
Permanent Link: http://hdl.handle.net/11104/0219552