Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

0389310 - ÚEM 2013 RIV US eng J - Journal Article
Rodríguez, J. J. - Jones, V. C. - Tabuchi, M. - Allan, S. M. - Knight, E.M. - LaFerla, F.M. - Oddo, S. - Verkhratsky, Alexei
Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease.
PLoS ONE. Roč. 3, č. 8 (2008), e2935. ISSN 1932-6203. E-ISSN 1932-6203
Institutional research plan: CEZ:AV0Z50390703
Keywords : hipocampus * Alzheimer's Disease
Subject RIV: FH - Neurology

Alzheimer's disease ( AD) is the primary and widespread cause of dementia and is an age-related, progressive and irreversible neurodegenerative disease that deteriorates cognitive functions. Here, we have used male and female triple transgenic mice (3xTg-AD) harbouring three mutant genes (beta-amyloid precursor protein, presenilin-1 and tau) and their respective non-transgenic (non-Tg) controls at 2, 3, 4, 6, 9 and 12 months of age to establish the link between AD and neurogenesis. Using immunohistochemistry we determined the area density of proliferating cells within the SGZ of the DG, measured by the presence of phosphorylated Histone H3 (HH3), and their possible co-localisation with GFAP to exclude a glial phenotype.
Permanent Link: http://hdl.handle.net/11104/0218204