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Estrogenic activity of bromidated flame retardants hexabromocyclododecane and tetrabromobisphenol-A on MCF-7 cells
- 1.0388667 - BTÚ 2013 CZ eng A - Abstract
Dorosh, Andriy - Děd, Lukáš - Elzeinová, Fatima - Pěknicová, Jana
Estrogenic activity of bromidated flame retardants hexabromocyclododecane and tetrabromobisphenol-A on MCF-7 cells.
Book of abstract. Praha: Biotechnologický ústav v. v. i. AVČR, 2010 - (Pěknicová, J.). s. 58-58
[XVI. symposium českých reprodukčních imunologů s mezinárodní účastí. 28.05.2010-30.05.2010, Žďár nad Sázavou]
R&D Projects: GA MŠMT(CZ) 1M06011; GA ČR(CZ) GA523/09/1793; GA ČR(CZ) GA523/08/H064; GA MŠMT(CZ) 2B06151
Institutional research plan: CEZ:AV0Z50520701
Keywords : Tetrabromobisphenol A * Hexabromocyclododecane * MCF-7 cell * RT-qPCR * Tff1 gene
Subject RIV: EB - Genetics ; Molecular Biology
The aim was to evaluate endocrine activity TBBPA and HBCD on MCF-7 cells. We used proliferation test in MCF-7 cells and RT-qPCR analysis of Tff1 estrogene-responsible reporter gene to analyze estrogenicity of studied compounds. We showed that HBCD has endocrine disrupting effects on organisms, including humans. TBBPA in accordance with previous results has no estrogenic effect mediated via endocrine receptor aplha.
Permanent Link: http://hdl.handle.net/11104/0218098
Number of the records: 1