Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation

0387566 - FGÚ 2013 GB eng J - Journal Article
Powell, A. D. - Gill, K. K. - Saintot, P.P. - Jiruška, Přemysl - Chelly, J. - Billuart, P. - Jefferys, J. G. R.
Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation.
Journal of Physiology. Roč. 590, č. 4 (2012), s. 763-775. ISSN 0022-3751. E-ISSN 1469-7793
Institutional research plan: CEZ:AV0Z50110509
Keywords : intellectual disability * synaptopathies * inhibition
Subject RIV: FH - Neurology
Impact factor: 4.380, year: 2012

Intellectual disability affects 2-3% of the population: those due to mutations of the X-chromosome are a major cause of moderate to severe cases. We investigated the pathophysiology of a mouse model of intellectual disability using electrophysiological recordings combined with confocal imaging of dentate gyrus granule neurons. Demonstrated deficits in inhibitory (as well as excitatory) synaptic transmission at frequencies associated with cognitive function suggests a cellular mechanism for the intellectual disability, because cortical oscillations associated with cognition normally depend on inhibitory neurons firing on every cycle
Permanent Link: http://hdl.handle.net/11104/0220295