Number of the records: 1
Mitochondrial Metabolism - Neglected Link of CancerTransformation and Treatment
- 1.0387401 - ÚFE 2013 RIV CZ eng J - Journal Article
Pokorný, Jiří - Jandová, Anna - Nedbalová, M. - Jelínek, František - Cifra, Michal - Kučera, Ondřej - Havelka, Daniel - Vrba, J. - Vrba, J. - Čoček, A. - Kobilková, J.
Mitochondrial Metabolism - Neglected Link of CancerTransformation and Treatment.
Prague Medical Report. Roč. 113, č. 2 (2012), s. 81-94. ISSN 1214-6994
R&D Projects: GA ČR(CZ) GAP102/11/0649
Institutional support: RVO:67985882
Keywords : Electromagnetic fields * Cellular biophysics * Cancer
Subject RIV: JB - Sensors, Measurment, Regulation
Mitochondria are at the boundary between chemical-genetic and physical processes of biological activity. Mitochondrial dysfunction in glycolytic cancer cells results in disturbed physical processes, very likely generated electromagnetic field, with consequent cell defective behavior-local invasion and metastasis. Cancer therapeutic strategy targeting mitochondria may restore physical functions of cells and open apoptotic pathway. Dichloroacetate treatment may lead to development of new anticancer drugs
Permanent Link: http://hdl.handle.net/11104/0216526
Number of the records: 1