0387370 - ÚIACH 2013 RIV US eng J - Journal Article
Doulliet, Ch. - Currier, J. M. - Saunders, J. - Bodnar, W. M. - Matoušek, Tomáš - Stýblo, M.
Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets.
Toxicology and Applied Pharmacology. Roč. 267, č. 1 (2013), s. 11-15. ISSN 0041-008X. E-ISSN 1096-0333
R&D Projects: GA MŠMT LH12040
Institutional support: RVO:68081715
Keywords : arsenic speciation * tissue * hydride generation
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 3.630, year: 2013 ; AIS: 1.021, rok: 2013
DOI: https://doi.org/10.1016/j.taap.2012.12.007

The insulin producing pancreatic β-cells are among the targets for As exposure and the inhibition of glucose stimulated insulin secretion by low concentrations of the methylated metabolites of iAs may be the key mechanism of iAs-induced diabetes.
Permanent Link: http://hdl.handle.net/11104/0217888