Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

0385635 - ÚJF 2013 RIV GB eng J - Journal Article
Staaf, E. - Brehwens, K. - Haghdoost, S. - Pachnerová Brabcová, Kateřina - Czub, J. - Braziewicz, J. - Nievaart, S. - Wojcik, A.
Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays.
Radiation Protection Dosimetry. Roč. 151, č. 3 (2012), 570-579. ISSN 0144-8420. E-ISSN 1742-3406
Institutional research plan: CEZ:AV0Z10480505
Keywords : chinese-hamster cells * peripheral-blood lymphocytes * linear-energy-transfer
Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders
Impact factor: 0.909, year: 2012

Exposure of humans to mixed fields of high- and low-linear energy transfer (LET) radiation occurs in many situations. From the perspective of health risk associated with exposure to mixed fields, it is important to understand the interactions between different radiation types. In most cellular investigations on mixed beams, two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. The authors have constructed a facility where cells can be simultaneously exposed to Am-241 alpha particles and 190-kV X-rays at 37C. This study presents the technical details and the dosimetry of the setup, as well as validates the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness of the alpha particles was 2.56 for 37 and 1.90 for 10 clonogenic survival.
Permanent Link: http://hdl.handle.net/11104/0007316