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Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro
- 1.0385207 - FGÚ 2013 RIV CZ eng J - Journal Article
Konopková, Renata - Világi, I. - Borbély, S. - Kubová, Hana - Otáhal, Jakub
Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro.
Physiological Research. Roč. 61, č. 2 (2012), s. 215-219. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LC554; GA AV ČR(CZ) 1QS501210509; GA ČR(CZ) GD305/08/H037
Institutional research plan: CEZ:AV0Z50110509
Keywords : Endothelin-1 * excitability * hippocampus * somatosensory cortex * rat * epileptogenesis
Subject RIV: FH - Neurology
Impact factor: 1.531, year: 2012
Endothelin-1 (ET-1) is a neuroactive protein produced in most brain cell types and participates in regulation of cerebral blood flow and blood pressure. In addition to its vascular effects, ET-1 affects synaptic and nonsynaptic neuronal and glial functions. Direct application of ET-1 to the hippocampus of immature rats results in cerebral ischemia, acute seizures, and epileptogenesis. Here, we investigated whether ET-1 itself modifies the excitability of hippocampal and cortical circuitry and whether acute seizures observed in vivo are due to nonvascular actions of ET-1
Permanent Link: http://hdl.handle.net/11104/0214540
Number of the records: 1