0384538 - ÚFCH JH 2013 RIV DE eng J - Journal Article
Šelešovská, R. - Bandžuchová, L. - Navrátil, Tomáš
Voltammetric Behavior of Methotrexate Using Mercury Meniscus Modified Silver Solid Amalgam Electrode.
Electroanalysis. Roč. 23, č. 1 (2011), s. 177-178. ISSN 1040-0397. E-ISSN 1521-4109
R&D Projects: GA AV ČR IAA400400806
Institutional research plan: CEZ:AV0Z40400503
Keywords : methotrexate * voltammetry * determination
Subject RIV: CG - Electrochemistry
Impact factor: 2.872, year: 2011 ; AIS: 0.585, rok: 2011
DOI: https://doi.org/10.1002/elan.201000440

Voltammetric behavior of methotrexate (MTX), an important chemotherapeutic drug, has been investigated using electrochemical methods: cyclic voltammetry, direct current voltammetry and differential pulse voltammetry on a mercury meniscus modified silver solid amalgam electrode (m-AgSAE). The obtained results have been compared with those obtained using a hanging mercury drop electrode (HMDE). The optimal conditions for its determination have been found in a Britton-Robinson buffer of pH 5 with the limit of detection equal to 1.8 nM. RSD at this concentration level amounted to less than 4%. The proposed procedure of determination was verified on a real drug containing MTX.
Permanent Link: http://hdl.handle.net/11104/0214155